IP3 Receptor-mediated Ca Release Facilitates RyR-Ca Release To Cause Inotropy And Arrhythmogenicity In Mouse Ventricular Myocytes
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منابع مشابه
IP3 receptor-dependent Ca release modulates excitation-contraction coupling in rabbit ventricular myocytes
Domeier TL, Zima AV, Maxwell JT, Huke S, Mignery GA, Blatter LA. IP3 receptor-dependent Ca release modulates excitation-contraction coupling in rabbit ventricular myocytes. Am J Physiol Heart Circ Physiol 294: H596–H604, 2008. First published November 30, 2007; doi:10.1152/ajpheart.01155.2007.— Inositol 1,4,5-trisphosphate (IP3) receptor (IP3R)-dependent Ca signaling exerts positive inotropic, ...
متن کاملStretch-induced Ca release via an IP3-insensitive Ca channel
Mohanty, Madhumita Jena, and Xingli Li. Stretchinduced Ca2 release via an IP3-insensitive Ca2 channel. Am J Physiol Cell Physiol 283: C456–C462, 2002. First published May 15, 2002; 10.1152/ajpcell.00057.2002.—Various mechanical stimuli increase the intracellular Ca2 concentration ([Ca2 ]i) in vascular smooth muscle cells (VSMC). A part of the increase in [Ca2 ]i is due to the release of Ca2 fro...
متن کاملSarcoplasmic reticulum Ca release in intact ventricular myocytes.
Sarcoplasmic reticulum (SR) Ca release in intact ventricular myocytes is the major source of Ca which activates cardiac contraction (although Ca influx makes a non-negligible contribution in most species). The fundamental events of SR Ca release are known as Ca sparks. The twitch Ca transient is composed of approximately 10,000 Ca sparks occurring in a given cell, and they are synchronized by t...
متن کاملEndothelin 1 Stimulates Ca -Sparks and Oscillations in Retinal Arteriolar Myocytes via IP3R and RyR-Dependent Ca Release
METHODS. Et1 responses were imaged from Fluo-4–loaded smooth muscle in isolated segments of rat retinal arteriole using confocal laser microscopy. RESULTS. Basal [Ca ]i, subcellular Ca 2 -sparks, and cellular Ca -oscillations were all increased during exposure to Et1 (10 nM). Ca -spark frequency was also increased by 90% by 10 nM Et1. The increase in oscillation frequency was concentration depe...
متن کاملIP3 Constricts Cerebral Arteries via IP3 Receptor–Mediated TRPC3 Channel Activation and Independently of Sarcoplasmic Reticulum Ca Release
Vasoconstrictors that bind to phospholipase C–coupled receptors elevate inositol-1,4,5-trisphosphate (IP3). IP3 is generally considered to elevate intracellular Ca concentration ([Ca ]i) in arterial myocytes and induce vasoconstriction via a single mechanism: by activating sarcoplasmic reticulum (SR)-localized IP3 receptors, leading to intracellular Ca release. We show that IP3 also stimulates ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2009
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2008.12.2790